Recently, research efforts aiming to improve energy efficiency of wastewater treatment processes for large centralized wastewater treatment plants (WWTPs) have been increasing. Global warming impacts, energy sustainability, and biosolids generation are among several key drivers towards the establishment of energy-efficient WWTPs. WWTPs have been recognized as major contributors of greenhouse gas emissions as these are significant energy consumers in the industrialized world. The quantity of biosolids or excess waste activated sludge produced by WWTP will increase in the future due to population growth and this pose environmental concerns and solid waste disposal issues. Due to limited capacity of landfill sites, more stringent environmental legislation, and air pollution from incineration sites, there is a need to rethink the conventional way of dealing with wastewater and the sludge production that comes with it. This book provides an overview of advanced biological, physical and chemical treatment with the aim of reducing the volume of sewage sludge.