This book constitutes the refereed proceedings of the 15 Ibero-American Conference on Artificial Intelligence, IBERAMIA 2016, held in San José, Costa Rica, in November 2016. The 34 papers presented were carefully reviewed and selected from 75 submissions. The papers are organized in the following topical sections: knowledge engineering, knowledge representation and probabilistic reasoning; agent technology and multi-agent systems; planning and scheduling; natural language processing; machine learning; big data, knowledge discovery and data mining; computer vision and pattern recognition; computational intelligence soft computing; AI in education, affective computing, and human-computer interaction.