This book explores the differential effects of a context-based learning approach on the performance and retention of organic chemistry concepts among male and female students in Ghana. Drawing on extensive research and real-world classroom applications, it examines how contextualizing chemistry lessons enhances understanding, bridges gender-based learning gaps, and fosters long-term retention of scientific concepts. The book offers practical strategies for educators, focusing on tailoring instruction to diverse learner needs, and provides valuable insights into improving gender equity in science education. It is an essential resource for educators, researchers, and policymakers striving to enhance science teaching outcomes in Ghana and beyond.