ANT Skin Barrier Support Supplement. Benefits: The filaggrin gene (filament aggregating protein) plays an important role in maintaining skin barrier integrity, preventing de-hydration, as well as preventing pathogens and irritants from getting through the skin barrier. Those with eczema may have fewer copies of the FLG gene, resulting in less functional filaggrin protein in the epidermis, less natural moisturization factor, and a leakier skin barrier.. : :