This monograph deals with the susceptibility issues in the development of an effective response to antigenicity as presented by emerging or established neoplastic lesions. An attempt has been made to present critical views of the dysfunction of carcinogenesis in terms of evolving immune responses in terms of recruitment of dendritic cell biology. It is within such conceptual framework that autoimmunity presents an attractive response to neoplasia in terms that allow for access to the malignant transformation process. It is significant to potentiate the immune responses that involve the integral immune dimensions that characterize and recharacterize the dynamics of turnover of dendritic cells as the most powerful agents in presentation of neoantigenicity as provided by tumor cell proliferation and spread within the body. The performance of staged dimensions in antigen exposure by tumor cells is critical to the presentation of tumor cells as brought forward by the proposed dynamics of an interface between tumor cells and the tumor microenvironment in the realization of an extensive autoimmune response with the realization of performance exposure of the antigenicity as a biologic agent in its own right. This book is aimed to cancer researchers, pathologists, and immunologists with a strong interest in carcinogenesis and cancer cell progression as dictated by proposed immune response to tumor antigenicity.