After being lost for centuries, the Vampyrnomicon, the Book of the Undead, is unearthed and with it the terrible secret of the vampires' origins. The book's discovery gives vampire hunter Drake Matthews the means to defeat Chiang Shih and her nest. It also provides Chiang Shih with the knowledge required to make vampires immortal. When Chiang Shih raises an army of the undead and establishes a vampire nation in Washington D.C., she cripples Drake and his hunters. Driven by vengeance, and with his ranks swelled by unlikely allies, Drake leads the survivors back into the infested city. With the fate of humankind hanging in the balance, hunters and vampires wage the final apocalyptic battle in the streets of Washington to determine who will hold dominion over the earth.