This book argues that public health thinking needs an overhaul, a return to and modernisation around ecological principles. Ecological Public Health thinking, outlined here, fits the twenty-first century’s challenges. It integrates what the authors call the four dimensions of existence: the material, biological, social and cultural aspects of life. Public health becomes the task of transforming the relationship between people, their circumstances and the biological world of nature and bodies. For Geof Rayner and Tim Lang, this is about facing a number of long-term transitions, some well recognized, others not. These transitions are Demographic, Epidemiological, Urban, Energy, Economic, Nutrition, Biological, Cultural and Democracy itself. The authors argue that identifying large scale transitions such as these refocuses public health actions onto the conditions on which human and eco-systems health interact. Making their case, Rayner and Lang map past confusions in public health images, definitions and models. This is an optimistic book, arguing public health can be rescued from its current dilemmas and frustrations. This century’s agenda is unavoidably complex, however, and requires stronger and more daring combinations of interdisciplinary work, movements and professions locally, nationally and globally. Outlining these in the concluding section, the book charts a positive and reinvigorated institutional purpose.