Empirical Research in Information Systems: 2001-2015 provides a first step in providing empirical evidence and knowledge about the practical relevance of IS research. The monograph first develops a broad yet sufficiently fine-grained framework of IS research by integrating earlier frameworks. It then identifies all empirical IS research published from 2001 to 2015 in four top IS journals (Journal of the Association for Information Systems, Journal of Management Information Systems, Information Systems Research, and MIS Quarterly), and maps onto this framework all the constructs and relationships that were examined by the 1,361 empirical papers published in this 15-year period. Next, based on this mapping and by drawing on criteria proposed by organizational and IS researchers, it provides a preliminary assessment of the relevance of empirical IS research to practice, and discusses the study’s findings and their implications.