This book is an invitation to question conventional and often misleading visions of globalization. No problem is global by nature: issues are transformed by the action of claims-makers to become ‘problems’ debated in supra-national forums, triggering policy choices and policy transformations. Contributions highlight how health issues, environmental issues and/or political issues are framed as global by a set of stakeholders (scientific experts, bureaucrats, political parties or actors, social movements, social networks, firms). As the volume maps the social logic behind the globalization of problems, it also presents an opportunity for the very cross-disciplinary collaboration it calls for: researchers mobilizing the “agenda-setting” paradigm of issue globalization and those working within the “social constructionist” model are both represented here, providing a unique opportunity to examine the dynamics of globalization from the perspectives of (political, media, economic) sociology, international relations, social movement studies, and beyond.