This book constitutes revised and selected papers from the Second International Congress on High-Performance Computing and Big Data Analysis, TopHPC 2019, held in Tehran, Iran, in April 2019. The 37 full papers and 2 short papers presented in this volume were carefully reviewed and selected from a total of 103 submissions. The papers in the volume are organized acording to the following topical headings: deep learning; big data analytics; Internet of Things.- data mining, neural network and genetic algorithms; performance issuesand quantum computing.