This book details the development of methods and models to study the HIV-1 viral reservoir with the ultimate goal of achieving a functional cure of HIV infection. Chapters are divided into six parts covering cell lines,
in vitro
and
ex vivo
primary cell models of persistent infection,
tissue-derived models, infected animal models human immune cells, methods of detection and analysis of the reservoir, and current approaches to achieve either a functional cure or cART-free long-term remission. Written in the format of the highly successful
Methods in Molecular Biology
series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible prools.
Authoritative and cutting-edge,
HIV Reservoirs: Methods and Prools
provides a comprehensive, updated collection of state-of-art methodologies and models to tackle the HIV-1 viral reservoir.