This volume constitutes the refereed proceedings of the 4th International Conference on Information Systems, Technology and Management, ICISTM 2010, held in Bangkok, Thailand, in March 2010. The 28 revised full papers presented together with 3 keynote lectures, 9 short papers, and 2 tutorial papers were carefully reviewed and selected from 86 submissions. The papers are organized in topical sections on information systems, information technology, information management, and applications.