Due to the complexity of the mihondrial system and the myriad genes involved in their function, the clinical manifestations of mihondrial diseases are remarkably variable and heterogeneous. The laboratory and clinical methodologies used to evaluate dysfunction may vary widely, and thusly a systematic presentation of the numerous prools that are applied to the assessment of these clinically and genetically heterogeneous disorders has proven to be essential.
Mihondrial Disorders: Biochemical and Molecular Analysis
strives to fill this need with a collection of key prools provided by leading experts in the field. Beginning with overviews of complexity of mihondrial and nuclear genome disorders, the book continues with a section devoted to current biochemical prools and a part focused on the DNA-based approaches used to identify molecular defects. Written in the highly successful
Methods in Molecular Biology™
series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.
Detailed and authoritative,
serves as a vital guide to researchers seeking to understand this incredibly complicated type of breakdown in cellular biology.