Molecules Engineered Against Oncogenic Proteins and Cancer
A comprehensive review of the latest molecular advances in cancer treatment
Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved,
documents the recent scientific advances that have transformed one of medicine’s most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented.
With a very well-known chemist as an author,
includes information on:
Each molecule’s structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action
Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent
History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer
The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field
Combining the most significant recent discoveries in a unique and useful way,
is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.