Spider-Man and Deadpool - teaming up?! That's right - and the web-slinger and the Merc with a Mouth are the double act of your dreams! Legendary DEADPOOL creative team Joe Kelly and Ed McGuinness reunite to make this team-up everything you ever hoped for. But will a fledgling friendship turn sour when Wade Wilson's next target turns out to be…Peter Parker?! Someone is messing with our wascally wisecrackers, and they've blended the genes of our heroes to create one murderous, mixed-up miss named Itsy Bitsy. She's Spidey and 'Pool's "daughter" - and she has seriously creepy daddy issues! Plus: More big-name creators join the fun as Deadpool goes Hollywood, our duo shares a retro adventure, Wade & Peter meet Penn & Teller, and Spidey and 'Pool are the only ones who can save Christmas! Collecting SPIDER-MAN/DEADPOOL #1-14, #17-18 and #1.MU.