Your immune system is as unique as your DNA, shaped by genetic inheritance, environmental exposures, and epigenetic modifications that influence how your body fights infections, responds to vaccines, and even determines your risk for autoimmune diseases, cancer, and chronic inflammation. But what if we could decode the genetic blueprint that governs these immune response, and even modify it? In The Immunogenome, examine how advances in immunogenomics, epigenetics, and systems biology are transforming our understanding of immune function, and why genetic polymorphisms, regulatory elements, and environmental factors contribute to differential susceptibility. This book delves into the intricate mechanisms by which transcriptional regulation, DNA methylation, histone modifications, and non-coding RNAs modulate immune gene expression inducing long-lasting epigenetic reprogramming of immune pathways. By bridging molecular immunology with precision medicine, The Immunogenome presents an encyclopedic framework for understanding how genetic and epigenetic networks govern immunological resilience and dysfunction.