Application of the concepts and methods of topology and geometry have led to a deeper understanding of many crucial aspects in condensed matter physics, cosmology, gravity and particle physics. This book can be considered an advanced textbook on modern applications and recent developments in these fields of physical research. Written as a set of largely self-contained extensive lectures, the book gives an introduction to topological concepts in gauge theories, BRST quantization, chiral anomalies, sypersymmetric solitons and noncommutative geometry. It will be of benefit to postgraduate students, educating newcomers to the field and lecturers looking for advanced material.