Excerpt from A Contribution to the Study of the Nature and Origin of the Bence Jones Protein: Dissertation
This study is a continuation of the preliminary work by Ottenberg and Gies who found in this laboratory that crude elastose, after its subcutaneous or intraperitoneal injection, can readily be detected in the urine by the heat precipitation test. Since the Bence Jones protein has various properties in common with elastoses, Ottenberg and Gies suggested that osseoalbumoid (bone elastin might be the forerunner of the Bence Jones protein, which appears in the urine of people with multiple myeloma of the bones.
It was thought that perhaps the osseoalbumoid of the bone might be so acted upon by the enzymes present in the cells of the myelomatous growth, as to give rise to a body having the properties of the Bence Jones protein.
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