This book is a collection of contributions presented at the 16th Conference on Acoustic and Vibration of Mechanical Structure held in Timişoara, Romania, May 28, 2021. The conference focused on a broad range of topics related to acoustics and vibration, such as noise and vibration control, noise and vibration generation and propagation, effects of noise and vibration, condition monitoring and vibration testing, modelling, prediction and simulation of noise and vibration, environmental and occupational noise and vibration, noise and vibration attenuators, biomechanics and bioacoustics. The book also discusses analytical, numerical and experimental techniques applicable to analyze linear and non-linear noise and vibration problems (including strong nonlinearity) and it is primarily intended to emphasize the actual trends and state-of-the-art developments in the above mentioned topics. The primary audience of this book consist of academics, researchers and professionals, as well as PhD students concerned with various fields of acoustics and vibration of mechanical structures.