Literature and its interactions with other disciplines such as history, philosophy, anthropology, the visual and multimedia arts, social sciences, medicine, technologies, are at the core of many potential and multifaceted investigations, originating within literary discourse itself. Through these multifarious multidisciplinary approaches, literature can be seen as a complex and dynamic system, in which issues of cross-cultural contact can be tackled from different theoretical and methodological points of view. This volume focuses on the philosophical and scientific debate on cultural contact by investigating the critical implications of these dynamics through multidisciplinary perspectives to literary studies, and bridging the gap between apparently divergent approaches.