This two-volume set of LNCS 12736-12737 constitutes the refereed proceedings of the 7th International Conference on Artificial Intelligence and Security, ICAIS 2021, which was held in Dublin, Ireland, in July 2021. The conference was formerly called “International Conference on Cloud Computing and Security” with the acronym ICCCS. The total of 93 full papers and 29 short papers presented in this two-volume proceedings was carefully reviewed and selected from 1013 submissions. Overall, a total of 224 full and 81 short papers were accepted for ICAIS 2021; the other accepted papers are presented in CCIS 1422-1424. The papers were organized in topical sections as follows: Part I: Artificial intelligence; and big data Part II: Big data; cloud computing and security; encryption and cybersecurity; information hiding; IoT security; and multimedia forensics