The 47 full papers included in the proceedings were carefully reviewed and selected from 70 submissions. They were organized in the following topical sections: Part I: Personalised Healthcare and Medicine; AI driven early diagnosis and prevention; AI driven robotics for healthcare; AI in mental health; Part II: AI in proactive care and intervention; AI-aided medical imaging and analysis; Medical signal and image processing; Assisted living technology; Digital twinning, virtual pathology and oncology; Patient data, privacy and ethics.