In the three years since the onset of COVID-19 we are still reeling from the reality of death and suffering on a massive scale, as well as ongoing economic and social dislocations. And yet, amidst the efforts to recover some lost sense of normality, there remain urgent issues to be addressed. Some of these bear on the ecological consequences of humankind’s unending encroachment on the natural world—one of the underlying factors in this and possible future pandemics. But then there are the spiritual lessons to be learned as well. As Diarmuid O’Murchu argues, the pandemic calls for a “reset,” a major shift in human consciousness, in the very ways we see and understand life—or fail to do so.