Three general accounts of causation stand out in early modern philosophy: Cartesian interactionism, occasionalism, and Leibniz's preestablished harmony. The contributors to this volume examine these theories in their philosophical and historical context. They address them both as a means for answering specific questions regarding causal relations and in their relation to one another, in particular, comparing occasionalism and the preestablished harmony as responses to Descartes's metaphysics and physics and the Cartesian account of causation. Philosophers discussed include Descartes, Gassendi, Malebranche, Arnauld, Leibniz, Bayle, La Forge, and other, less well-known figures.