In the light of digital transformation and the role of information and communication technologies for economic development, this volume discusses the challenges and opportunities for a new digital economy and regional and sustainable development of countries in the Balkans and Eastern Europe. It features selected contributions on topics such as regional economic growth, e-government strategies, the role of global value chains, smart cities and other issues related to digital transformation. The book will appeal to scholars and practitioners in economics, regional science, business and management, as well as those interested in sustainable urban and regional ecosystems.