This book constitutes the refereed proceedings of the 10th IFIP WG 6.1 International Conference on Distributed Applications and Interoperable Systems, DAIS 2010, held in Amsterdam, The Netherlands, in June 2009. The DAIS conference was held as part of the federated event on Distributed Computing Techniques (DisCoTec), together with the 12th International Conference on Coordination Models and Languages (Coordination 2010), the 12th Formal Methods for Open Object-Based Distributed Systems and the 30th Formal Techniques for Networked and Distributed Systems (FMOODS/FORTE 2010). The 17 revised full papers presented were carefully reviewed and selected from53 submissions. The papers are organized in topical sections on ubiquitous services and applications, grid computing, sensor networks, context awareness, service orientation, distributed fault tolerant controllers, cloud and cluster computing, adaptive and (re)configurable systems, and collaborative systems.