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DNA-Encoded Chemical Libraries: Methods and Protocols
Barnes and Noble
DNA-Encoded Chemical Libraries: Methods and Protocols
Current price: $169.99
Barnes and Noble
DNA-Encoded Chemical Libraries: Methods and Protocols
Current price: $169.99
Size: Hardcover
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This volume discusses prools that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful
series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive,
is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.