This book presents 501 plant species found in Odisha, along with their ethnobotanical values and socio-religious significance. It encompasses various uses such as food, fodder, medicine, timber, fuel, artifacts, rituals, and biofencing. The species are organized according to the APG III (2009) system of classification, providing updated information at the family level. While taxonomic aspects, including morphological and ecological characteristics, are briefly discussed, the book primarily aims to provide accessible information to a general audience, avoiding excessive technical details. Photograph of all plant species collected from their natural habitat is given. The intention is to inspire emerging naturalists, herbalists, and individuals interested in exploring the medicinal uses of biodiversity. The book recognizes the necessity of researching plant species, including their phytochemistry, pharmacological activity, and therapeutic applications. It also highlights the economic advantages of harnessing medicinal plants. As a comprehensive resource, the book enables readers to understand the ethnobotanical values associated with plant species in Odisha.