This book constitutes the thoroughly refereed proceedings of the 10th International Conference on Evaluation of Novel Approaches to Software Engineering, ENASE 2015, held in Barcelona, Spain, in April 2015. The 10 full papers presented were carefully reviewed and selected from 74 submissions. The papers reflect a growing effort to increase the dissemination of new results among researchers and professionals related to evaluation of novel approaches to software engineering. By comparing novel approaches with established traditional practices and by evaluating them against software quality criteria, the ENASE conferences advance knowledge and research in software engineering, identify most hopeful trends, and propose new directions for consideration by researchers and practitioners involved in large-scale software development and integration.