The advent of digital and computing technologies has created a surge in the development of AI methodologies and their penetration to a variety of activities in our daily lives in recent years. Indeed, researchers and practitioners have designed and developed a variety of AI-based systems to help advance health and well-being of humans. In this first volume, we present a number of latest studies in AI-based tools and techniques from two broad categories, viz., medical signal, image, and video processing as well as healthcare information and data analytics in Part 1 and Part 2, respectively. These selected studies offer readers practical knowledge and understanding pertaining to the recent advances and applications of AI in the healthcare sector.