In this, the bio- factor becomes not only relevant but also an amplifier: using the technology malevolently, all the advances made to combat disease may be used to cause, further, or perplex and complicate disease. Improved or totally novel or even alien germs may replace explosives in bombs, shells or suicidal /kamimaze drones and taint bullets and fragments. Microrobots may deliver cancer cells to targeted individuals to foster cancer, or specific supergerms for an infection to rage unchallenged. And what happens if the mechanism of these cancers and infections is intentionally provided with an Abort signal? Global extortions would become probable, not just possible. Far from Science Fiction, this dystopia becomes more probable by the day. The Artificial Intelligence simply makes it easier to occur. Technology allows manipulation and intervention in levels and extends only imagined in the Past, but the application of these capabilities is clearly of dual use, with the destructive potential leveraged by the complexity of the social and state structure. Within this book, we explore the “How” (occasionally the “What” also) in some of these instances. From cyber terrorists to aggressive bioindustrialists and “democratized” ballistic and cruise missile technology, it could be coined as "The Book of Modern Mayhem”.