This detailed book explores the interactions between different types of cells and immune cells, focusing on how their functionality is affected by immunosenescence. Beginning with traditional approaches, such as quantifying TRECs and measuring telomere lengths, the book continues with chapters on characterization of immune cell populations in aging, immune cell signaling, transcription factors, gene expression profiles, and the production of soluble factors such as cytokines, as well as computational approaches and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory prools, as well as tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Immunosenescence: Methods and Prools serves as an ideal guide for researchers working in this vital area of immunology and cell biology.