This work represents a study of the hunter-gatherer societies that occupied the Central Plateau of Santa Cruz, with a special focus on La María Archaeological Locality. The broad objective is to try and understand the technological organization of the groups which lived in this area between the final Pleistocene and the late Holocene, and by so doing provide a discussion on the issues relating to other aspects of the society, such as the economic and social strategies of mobility, the use of the space and the exploitation of economic resources implemented in the different periods studied. Other specific objectives include: to identify the environmental changes which occurred since the beginning of the first human occupation in the region; to establish the regional structure of lithic resources; to analyze the variability of the set of artefacts; to characterize the sequences of artefact production for each raw material; to analyze the design of the artefacts; to define the different ways lithic technology was organized in every temporal range; to understand if there were differential technical skills for each of these particular episodes; and, to analyze the different ways the region was occupied during these specific temporal contexts. Full Title: La organización tecnológica en grupos cazadores recolectores desde las ocupaciones del Pleistoceno final al Holoceno tardío, en la Meseta Central de Santa Cruz, Patagonia