These proceedings showcase the best papers selected from more than 500 submissions, and introduce readers to the latest research topics and developmental trends in the theory and application of MMESE. The integrated research topic Man–Machine–Environment System Engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Long from October 22nd, 1993, Qian wrote: “You have created a very important modern science and technology in China!”