The 65 full papers presented were carefully reviewed and selected from 95 submissions. They were organized according to following topical sections: biomarker detection; image registration, and reconstruction; image segmentation; generative models, biomedical simulation and modelling; classification; image enhancement, quality assessment, and data privacy; radiomics, predictive models, and quantitative imaging. Chapter “FCN-Transformer Feature Fusion for Polyp Segmentation” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.