The following text field will produce suggestions that follow it as you type.

Barnes and Noble

Mitochondrial DNA, Mitochondria, Disease and Stem Cells

Current price: $169.99
Mitochondrial DNA, Mitochondria, Disease and Stem Cells
Mitochondrial DNA, Mitochondria, Disease and Stem Cells

Barnes and Noble

Mitochondrial DNA, Mitochondria, Disease and Stem Cells

Current price: $169.99

Size: Hardcover

Loading Inventory...
CartBuy Online
*Product information may vary - to confirm product availability, pricing, shipping and return information please contact Barnes and Noble
This volume investigates how the mihondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mihondrial disease. It also highlights the importance of the mihondrial assembly factors and how mutations to these can lead to mihondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mihondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mihondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mihondrial DNA and dysfunctional mihondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

More About Barnes and Noble at The Summit

With an excellent depth of book selection, competitive discounting of bestsellers, and comfortable settings, Barnes & Noble is an excellent place to browse for your next book.

Powered by Adeptmind