This book provides a multi-author systematic look at this subject, fro m neurobiological bases to clinical applications. It includes four sec tions dealing with fundamental aspects of cortical excitability, model s of epileptic disorders, targets for anti-epileptic drugs and rationa l approaches to therapy. Each chapter provides a review of a specific topic prepared by well known scientists active in the field, introduci ng their most recent results in a concise and comprehensive form.