This volume presents the work of ten scholars who shared their research at the Denver Art Museum’s 2017 symposium hosted by the Frederick and Jan Mayer Center for Pre-Columbian and Spanish Colonial Art. Centered on the theme of murals, each chapter discusses how this art form functions as a powerful tool for the expression of political, social, or religious ideas across diverse time periods and cultures in the Americas, from the ancient rock cave paintings of Guerrero, Mexico, to the murals of the 1960s Chicano movement.