The body of a beautiful young Cherokee casino worker is found under a bridge on the highway leading into Cherokee, North Carolina. It is linked with an earlier, similar murder of a young Cherokee school teacher a few miles away in Benton, Tennessee on a Cherokee monument. As murders continue to occur, it becomes apparent that there is a serial killer out there who is targeting these victims and he is willing to take out anyone who gets in his way. FBI investigators, A.J. Waters and Uley Barlow, must use all their skills to solve the murders and stop this killer before the next new moon appears and another ritualistic murder takes place.