Just as her medical career is reaching its zenith, superstitious janitor Harriet Spilman is losing everything. Her common law husband is cheating with her boss's nymphomaniacal wife, while her boss is losing his esteemed surgical clinic to a witch's brew of drugs and alcohol. As a Ken-and-Barbie pair of con artists launch an extortion scheme, a self-loathing Native American transgender repo man inadvertently fulfils his father's prophecy when he falls in love with Harriet. Will Harriet's voodoo save the day? Or is it just a bunch of bullshit?