William Powell plays a condemned murderer who is being transported from Hong Kong to San Quentin by way of a luxury liner. Also on board is the lovely Kay Francis, who is suffering from a fatal heart condition. The sympathetic detective (Warren Hymer) escorting Powell allows the prisoner to roam the decks without handcuffs, an opportunity Powell exploits by arranging an escape with two of his old cronies (Frank McHugh and Aline MacMahon). But when he meets Francis, Powell falls in love. Francis is equally smitten, and the two conduct an exquisite shipboard affair, neither telling the other of their impending doom. Powell makes his escape, but is halted in mid-flight when Francis has a heart attack. He rushes Francis back on board ship to her doctor, knowing full well that this will mean his recapture. As they bid goodbye, Powell and Francis promise to meet again one year later in Agua Caliente--a rendezvous that neither will survive to keep. A year passes. At a bar in Agua Caliente, two cocktail glasses suddenly shatter, as if having been joined in a toast by unseen hands. One Way Passage was remade in 1940 as 'Til We Meet Again.