The Healthcare sector is experiencing a mindset change with the advent of Healthcare 5.0, bringing forth improved patient care and system efficiency. However, this transformation poses significant challenges. The growing digitization of healthcare systems raises concerns about the security and privacy of patient data, making seamless data sharing and collaboration increasingly complex tasks. Additionally, as the volume of healthcare data expands exponentially, efficient handling and analysis become vital for optimizing healthcare delivery and patient outcomes. Addressing these multifaceted issues is crucial for healthcare professionals, IT experts, data scientists, and researchers seeking to fully harness the potential of Healthcare 5.0. Pioneering Smart Healthcare 5.0 with IoT, Federated Learning, and Cloud Security presents a comprehensive solution to the pressing challenges in the digitalized healthcare industry. This research book dives into the principles of Healthcare 5.0 and explores practical implementation through cloud computing, data analytics, and federated learning. Readers will gain profound insights into the role of cloud computing in managing vast amounts of healthcare data, such as electronic health records and real-time analytics. Cloud-based frameworks, architectures, and relevant use cases are explored to optimize healthcare delivery and improve patient outcomes.