Pamela Isley has been a lot of things in her life. A living god, a super-villain, an activist, a scientist, and dead. In a new body that she didn’t ask for and with a renewed sense of purpose, Ivy leaves Gotham and sets out to complete her greatest work—a gift to the world that will heal the damage dealt to it...by ending humanity. On her journey to doom humankind, a heartbroken and betrayed Poison Ivy encounters obstacles (plant assassins!) and dodges the law along the way, in a body horror-infused character-defining epic from the visionary creative team of writer G. Willow Wilson and artist Marcio Takara. This volume collects #1-6.