This collaborative monograph will commemorate the centenary of the Prague English Studies, officially inaugurated in 1912 by the appointment of Vilém Mathesius. Apart from reassessing the work of major representatives, such as Mathesius, Vladislav Vancura and others, and reviewing important developments in literature-oriented Prague English Studies with respect to Prague Structuralism. will focus on the methodological problems of the discipline related to the transformation of humanistic and modern philologies, searching for the links between two historically distinct interdisciplinary projects: humanist philology and structuralist semiology.