Part I sets the stage describing the evolution from process mining to process intelligence. The chapters guide the reader step by step, from getting started to driving adoption at scale. Success factors critical for digital transformations and a detailed path to value realization are presented. Best practices on operating models and Centers of Excellence (CoEs) are shared as accelerators for successful digital transformations. Part II presents 12 use cases written by transformation- and CoE leaders who have achieved significant impact and value with process intelligence in their respective organization. All use cases have been written independent from any particular software, with a focus on evangelizing the topic and showcasing how companies like ABB, BMW, Bosch, Merck, PepsiCo, Saint Gobin, Siemens, and others leverage the capability to drive value. Part III provides an outlook on the future of process intelligence from an academic and an operational perspective, with a special focus on the disruptive impact of GenAI with future scenarios, challenges and recommendations. The book is written by practitioners for practitioners. Readers may have responsibilities as senior executives, transformation leaders, process managers and experts, consultants, change evangelists, etc. The book provides operational, hands-on tips on how to accelerate process transformation in organizations by detailing best practices as well as possible pitfalls.