Prozac and its chemical cousins, Paxil, Celexa, and Zoloft, are some of the most profitable and most widely used drugs in America. Their use in the treatment of a multitude of disorders—from generalized anxiety disorder and premenstrual syndrome to eating disorders and sexual compulsions—has provoked a whirlwind of public debate. Talk shows ask, Why is Prozac so popular? What, exactly, do these drugs treat? But sustained critical discussion among bioethicists and medical humanists has been surprisingly absent.The eleven essays in provide the groundwork for a much-needed philosophical discussion of the ethical and cultural dimensions of the popularity of SSRI antidepressants. Focusing on the increasing use of medication as a means of self-enhancement, contributors from the fields of psychiatry, psychology, bioethics, and the medical humanities address issues of identity enhancement, the elasticity of psychiatric diagnosis, and the aggressive marketing campaigns of pharmaceutical companies. They do not question the fact that these antidepressants can, in some cases, provide great benefit to alleviate real suffering. What they do question is the abundant popularity of these drugs and that popularity's relationship to American culture and ideas of selfhood. Contributors:Tod Chambers, Northwestern University Feinberg School of Medicine, ChicagoDavid DeGrazia, George Washington UniversityJames C. Edwards, Furman UniversityCarl Elliott, University of Minnesota Center for BioethicsDavid Healy, University of Wales College of MedicineLaurence J. Kirmayer, McGill UniversityPeter D. Kramer, Brown UniversityErik Parens, The Hastings CenterLauren Slater, AfterCare Services, BostonSusan Squier, Pennsylvania State UniversityLaurie Zoloth, Northwestern University Center for Genetic Medicine, Chicago