This book tells the story of the HIV epidemic in South Africa, and asks why, after more than three decades, it has not normalised. Despite considerable efforts to prevent infection, and ambitious targets set to end the epidemic by 2030, HIV infections are increasing among young women and treatment uptake and adherence have been uneven. Focusing on the years preceding and following treatment access, this book addresses why an end to AIDS may be misplaced optimism. By examining public discourses and private narratives about infection, illness and death, this work reveals the contradictions between the lived experiences of AIDS suffering on the one hand, and biomedical certainties on the other. Based on long-term ethnographic research in rural villages of the South African lowveld, and within HIV prevention interventions in South Africa more generally, this book offers an intimate perspective on the social and cultural responses to the epidemic.