This book is the first volume that provides an unique overview of the most recent and relevant contributions in the field of mathematical physics with a focus on the mathematical features of quantum mechanics. It is a collection of review papers together with brand new works related to the activities of the INdAM Intensive Period "INdAM Quantum Meetings (IQM22)", which took place at the Politecnico di Milano in Spring 2022 at Politecnico di Milano. The range of topics covered by the book is wide, going ranging from many-body quantum mechanics to semiclassical analysis, quantum field theory, Schrödinger and Dirac operators and open quantum systems