The Rise of the Blood Moon follows sisters Sarah and Caitlin, two years after they defeated the dark sorcerer Lethanor. Their hard-earned peace is shattered when an ancient curse tied to the Blood Moon reawakens. Caitlin, now 14, unknowingly carries the curse in her blood, doomed by a fate set centuries ago.
As the Blood Moon rises, the sinister demon Nyxora seeks to use Caitlin's blood in a dark ritual that will open the gates of darkness. Sarah embarks on a desperate mission to save her sister, but when the ritual backfires, Caitlin is transformed, gaining control over the dark magic meant to enslave her. Caitlin must now face a future filled with dangerous new powers, while Sarah fights to keep their bond strong in the face of unimaginable threats.