Despite burgeoning interest, education, research, and advocacy efforts, a pinnacle handbook devoted to human trafficking and modern-day slavery – with global focus and multidisciplinary scope – does not currently exist. The was created to fill this resource gap. Divided into four sections, the offers the reader a comprehensive and fresh approach via: (a) in-depth analyses and opportunities for application (through case studies, critical thinking questions, and supplemental learning materials); (b) multidisciplinary linkages, with disciplinary overlap across each of the four sections acknowledged and highlighted; and (c) content experts representing multiple segments of society (academia, government, foundation, law enforcement, and practice) and global vantage points (Australia, Finland, Germany, Netherlands, South Africa, Thailand, and the United States). Written by expert scholars, service providers, policy analysts, and healthcare professionals, this is an invaluable resource for those already working in the field, as well as for students in any discipline who want to learn (or learn more) about HT and modern-day slavery.